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In the acute administration paradigm, animals received a single intraperitoneal infusion (over 30 minutes) of cisplatin at doses ranging from 9 mg/kg to 15 mg/kg, and were monitored for up to 7 days

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This selectivity makes FOXO4-DRI valuable for tissue engineering applications where elimination of senescent cells from expanded cell populations could improve research outcomes and provide researchers with enhanced cell preparation methods for regenerative medicine investigations

Though it was previously thought that EPO was solely a key gene in the maturation and proliferation of red lineage progenitors, later studies showed that it is widely expressed in mammalian brain cells, including neurons and glial cells, which also express EPO receptors (37)