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2i means the calculated theoretical additive radiosensitization effect of Gd-NTs and MbO 2 @NTs (assuming there was no synergistic effect), which was calculated by multiplying the survival inhibition ratios of Gd-NTs + RT and MbO 2 @NTs + RT according to the reported method 41

Whereas ultrasound and FNA have been the two most commonly used imaging techniques for thyroid nodule assessment, each has some drawbacks (Sturgeon and Kim 2021)