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HIV-Tat binding to the HIV-LTR (long terminal repeat) promoter using another viral RNA element, TAR (transactivation responsive region), plays a crucial role in the viral life cycle by enhancing transcription, particularly transcript elongation ( The first two domains of Tat are proline-rich and cysteine-rich, contributing to structural stability

Data have suggested this occurred through modulation of transforming growth factor beta (TGF-) pathway proteins, specifically mothers against decapentaplegic homolog 3 (Smad3)

Intra-tumour signalling entropy determines clinical outcome in breast and lung cancer

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