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The intracellular concentrations of vitamin B12 can be inferred through the total plasma concentration of homocysteine, which can be converted to methionine through an enzymatic reaction that uses 5-methyltetrahydrofolate as the methyl donor group

In anemia related to vitamin B12 deficiency, an appropriate B12-containing regimensometimes alongside iron or folate when indicatedhelps restore hematologic parameters and reduce neurologic symptoms when instituted promptly and correctly

International Journal of Radiation Oncology Biology Physics 99(2):E380-E380, 2017

The services listed in Table 26 may not be billed for a patient in the same month with APCM services by the same practitioner but may be billed when medically necessary for a patient in the same month by a practitioner other than the practitioner furnishing APCM services (HCPCS G0556, G0557, and G0558)