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The most apical part of the junctional complexes are tight junctions (TJs), which are highly specialized and dynamic supramolecular entities composed of several transmembrane proteins (such as the claudin family, junctional adhesion molecule (JAM)-A, occludin, tricellulin) and the cytoplasmic plaques comprised of scaffolding proteins [zonulae occludens (ZO-1, ZO-2, ZO-3, cingulin)] and effector proteins (8487) that provide a physical link to the cytoskeleton

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Front Oncol 2017 Mar 29;7:58 36

Composed of a sequence of 15 amino acids, the peptide can also be found in trace amounts in the gastric fluids of other mammals