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-22.5% Avg body weight loss at highest dose (SURMOUNT-1) 96% Lost at least 5% body weight 72 weeks Trial duration Context: Clinical trial participants also received lifestyle intervention (diet and exercise counseling)

H.ChevliakovM

Western blot analysis showed that MOR protein levels were significantly reduced in PVN Glu neurons of mice injected with AAV-DIO-shMOR-EGFP compared to AAV-DIO-EGFP-infected controls, validating the efficacy of MOR knockdown (Fig