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In some pathogens, the loss or mutation of these detoxification genes led to phenotypic defects even in the absence of added formaldehyde

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Similar findings were obtained in the NCT01757535 study, where the administration of CC-486 (300 mg for 14 days per 28-day cycle) + BSC as a maintenance treatment significantly enhanced both relapse-free survival and OS in de novo or secondary AML patients by reducing measurable residual disease (MRD) [342,343,344,345]