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doi: 10.1371/JOURNAL.PONE.0215435 29 AmbrosiniYMNeuberSBorcherdingDSeoYJSegarraSGlanemannBet al

The dataset contains 19,173,961 SNPs(The dataset is publicly available at the Google Cloud Storage location gs: 2.7 Statistical analysis Statistical analyses were conducted using R version 4.3.1 and software packages TwoSampleMR, MRPRESSO, and meta. The Inverse Variance Weighted (IVW) approach was used as the primary analytical method for MR to investigate the causal relationship between genetic variants associated with exposures and the outcome ( p -value 0.05 indicating heterogeneity and requiring the adoption of a Random Effects IVW method

Another study suggested that combined QE and simvastatin attenuated hepatic fibrosis in rats by lowering serum levels of GOT, GPT, ALP, decreasing hepatic mRNA levels of sphingosine kinases type 1 (SphK1) and NLRP3 and elevating total antioxidant capacity, glutathione and Nrf2 expression levels, suggesting that targeting the SphK1/NLRP3 pathway could be a prospective therapeutic strategy against liver fibrosis (Salama et al., 2024)

The data is striking: in a Phase 2 trial published in the New England Journal of Medicine, the highest doses produced an average ~24% body-weight reduction at 11 months more than any currently approved weight-loss drug (American Diabetes Association)