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Another proposed mechanism involves the binding of homocysteine to the collagenous matrix of bone, which may modify collagen properties and reduce bone strength (reviewed in 113)

Pharmaceutics 13:111 Falcone M, Meier JJ, Marini MG et al (2021) Diabetes and acute bacterial skin and skin structure infections

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This is a CagriSema, as you know, a combination of the GLP-1 receptor agonist semaglutide plus the long-acting amylin cagrilintide, so two different mechanisms of actions, two different compounds both affecting appetite in an additive way