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1.4 Glucocorticoid-Induced Osteoporosis Reclast is indicated for the treatment and prevention of glucocorticoid-induced osteoporosis in men and women who are either initiating or continuing systemic glucocorticoids in a daily dosage equivalent to 7.5 mg or greater of prednisone and who are expected to remain on glucocorticoids for at least 12 months [see Clinical Studies (14.4)]

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A 2026 review in Frontiers in Aging identified nine peptides spanning diverse aging interventions metabolic restoration, telomere biology, dermal regeneration, tissue repair, neuroprotection, and growth hormone modulation and concluded that mechanistically diverse approaches to multiple aging hallmarks represent the frontier of gerontological peptide medicine.2 The clinical principle is straightforward: address more pathways, produce more durable outcomes