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[5] Catabolically, lysine is predominantly metabolized in hepatic mitochondria through saccharopine and pipecolate pathways to yield acetyl-CoA, a process tightly regulated by lysine--ketoglutarate reductase and saccharopine dehydrogenase

Our findings raise the notion that reductions in key antioxidant mechanisms may be the biological risk factor for the development of konzo, particularly those mediated through pathways involving the glutathione peroxidase family

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