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Description

Report of a Joint FAO/WHO Expert Consultation

The circadian clock and the mutation of its components lead to alteration in response to oxidative stress ( The homeostasis of ROS is tightly regulated by antioxidant systems like Nrf2 transcriptional regulation which is also dependent on the circadian clock (Stangherlin and Reddy, 2013

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Safety and efficacy of methotrexate (0.3 mg/kg/week) versus a combination of methotrexate (0.15 mg/kg/week) with cyclosporine (2.5 mg/kg/day) in chronic plaque psoriasis: a randomised non-blinded controlled trial