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vulgaris , 5 genes for P

By identifying specific loxP sites, Cre facilitates the deletion of gene sequences located between these sites, enabling precise genetic modification at defined genomic loci

104 However, this route presents significant challenges: the acidic environment of the GI tract can degrade peptides, and impaired intestinal absorptionparticularly in IBD patients with compromised digestive functionfurther reduces bioavailability

Acknowledgements The authors gratefully acknowledge: librarians from the University of Queensland (Australia) and the University of Skvde (Sweden) for assistance with database search terms, and the University of Queensland librarians who also assisted with manuscript and figure preparation