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doi: 10.1111/j.1365-3040.2009.01944.x 125 MittlerR

However, the chemical composition of GSH does not allow it to be taken orally for central nervous system diseases because little to none crosses the blood-brain barrier

3 To prevent excessive oxidative stress and maintain favorable redox homeostasis, tumor cells have evolved a complex antioxidant defense system that strategically adjusts multiple antioxidant enzymes such as catalase, glutathione reductase, and antioxidant molecules