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Most MS studies utilize structural MRI for identifying lesions and determining if they are active based on gadolinium enhancement ( Materials and Methods Overview of Study Written informed consent, approved by the Institutional Review Board of Thomas Jefferson University, was obtained from all subjects and the study was registered on clinicaltrials.gov with the following identifier: NCT03032601

We converted raw PROMIS depression summary scores to T-scores using the conversion tables in the PROMIS scoring manual (healthmeasures.net 65 )

doi:10.3949/ccjm.75.1.57 PubMed 60

Moreover, while many of the reviewed studies reported promising feasibility and adherence to VR-based interventions, these results were mostly obtained in highly structured clinical or research environments