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2012;7(7):e41412 110

Current evidence suggests not only that glia may share some metabolic perturbations with retinal ganglion cells, but that they may also represent shared neuroprotective targets for glaucoma treatment

Kanazawa K, Yokouchi H, Wang X, Ishida T, Fujita Y, Fujiuchi S, et al

Mechanistically, retatrutide adds a third receptor (glucagon) that tirzepatide doesnt engage at all, and binds the GIP receptor far more tightly, so meaningful GIP engagement arrives at a fraction of the dose