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CAR-T cells expanded upon exposure to IL15 (CAR-T/IL15) exhibited a T SCM phenotype, which was closely associated with decreased mTORC1 activity and reduced expression of glycolytic enzymes [6]

Piribedil loaded thermo-responsive nasal in situ gelling system for enhanced delivery to the brain: formulation optimization, physical characterization, and in vitro and in vivo evaluation

Handling should be done in a well-ventilated environment to minimize the risk of inhalation of toxic vapors.90 Regarding the emulsifier, scientific literature recommends the preferred use of Novisol, due to its safety, compatibility with phenol, and role in emulsion stability, as demonstrated in stability studies of the Hetter formula.99,100 Finally, to reduce the risk of systemic toxicity, it is recommended that the total volume of phenol used in a single session does not exceed 10 mL, regardless of the concentration used.19,84 Emergency Interventions The presence of cardiopulmonary resuscitation equipment is mandatory for the management of serious adverse events, such as Acute Respiratory Distress Syndrome (ARDS) or cardiopulmonary arrest