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Additional symptoms of Cushing's disease may include: Panting Weight loss Lethargy Pot-bellied appearance Thin skin Hair loss Skin infections Calcified skin (firm, hardened tissue beneath the skin) Causes of Cushings Disease in Dogs Most cases of Cushings disease are caused by a benign pituitary gland tumor, although adrenal tumors and long-term steroid use can also lead to the condition

The poor oral bioavailability of BBR is compromised by P-glycoprotein (P-gp), an active efflux protein that depletes adenosine triphosphate and extrudes BBR into the intestinal lumen, thereby limiting its absorption

But before we get going, I've got to let my eccentric personality show through with a little bit of non-dolly blather