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This disturbance in gut microbiota is believed to be linked to the risk of CDI in patients with chronic metabolic liver diseases 21

Pain Ther 14 , 2145 (2025)

Although it has been argued that clinically relevant doses of APAP should be used in such studies, it is expected that recapitulating conditions in susceptible humans using healthy laboratory animals will require higher drug doses than those commonly encountered by humans (Fig