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A 2023 study found that combining GHK-Cu with low-molecular-weight hyaluronic acid synergistically upregulated collagen IV by more than 25-fold in fibroblast models and doubled expression in skin underscoring how topical peptides can maintain firmness and repair after systemic cycles ( Jiang et al., 2023, J Cosmet Dermatol )

Both skeletal muscle-specific GHR and IGF-1R knockout mice exhibited reduced myofiber size and number, and impaired muscle force, which are associated with diminished myoblast fusion