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The Merck group continued to utilize the spiroindanyl piperidine core and examined positions 3 and 4 off the spiroindane phenyl group with additional substitutions off of the spiroinanyl piperidine, and pyrrolidine amine substitutions ( 11 , Figure 3)

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Common Reconstitution Errors and How to Avoid Them Error 1: Adding Too Little or Too Much BWI Adding 1 mL instead of 2 mL to a 2 mg vial doubles the concentration