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Polyphyllin -Induced ferroptosis in MDA-MB-231 triple-negative breast cancer cells can Be protected against by KLF4-mediated upregulation of xCT

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However, ascorbic acid from fruits and vegetables and peptides from partially digested muscle tissue from meat, fish, and poultry can enhance iron absorption and offset some of the negative effects of phytic acid and polyphenols when consumed in a mixed diet [225, 279]

HSP90 also promotes tumor angiogenesis by enhancing the transcription and expression of vascular endothelial growth factor receptors (VEGFRs), which are essential for endothelial cell-dependent angiogenesis