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According to the World Obesity Atlas 2025 Report, the global prevalence of overweight and obesity among adults is projected to increase from 36% in 2000 to 50% by 2030 [5]

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Importantly, redox imbalance acts as the molecular bridge through which IR and HA reinforce each other while maintaining a chronic inflammatory state ( 2.4 Redox-endocrine vicious cycle in PCOS The pathophysiology of PCOS is underlined by a self-reinforcing redox-endocrine loop that integrates OS, hormonal dysregulation, and metabolic dysfunction into a persistent pathological circuit