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N Am J Med Sci

Because canonical Wnt signaling has been shown to be critical for the development of posterior lateral line neuromasts (Gamba et al., 2011

These are sensed by PRRs such as Toll-like receptors (TLRs), activating innate immune cells and amplifying inflammation

While in the foregoing specification this invention has been described in relation to certain preferred embodiments thereof, and many details have been set forth for purposes of illustration, it will be apparent to those skilled in the art that the invention is susceptible to additional embodiments and that certain of the details described herein may be varied considerably without departing from the basic principles of the invention