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Also, there is a growing interest in exploring less-common carotenoids, especially those with longer carbon chains, as they are increasingly demonstrating superior bioactivity compared to the more extensively studied shorter-chain carotenoids, highlighting the need to expand current research efforts to fully uncover their distinct biological roles and potential clinical applications

Vitamin E was obtained from Mepaco Company, Egypt

Internal standards (13C6-L-Arginine, 13C5-L-Valine, 13C2-Citric acid, 2H4-Succinic acid and 13C6-Fructose-6-phosphate) were added, followed by homogenisation, sonication, and centrifugation

Several factors, including the expression of SLC7A11/SLC3A2, CD8+ T cell levels and IFN- concentrations, can influence the prognosis of patients with LC (133)