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Rev Paul Pediatr

6 Conclusion and outlook The intricate ferroptosis-immune-metabolic axis has emerged as a central driver of COPD pathogenesis, creating a self-perpetuating cycle of inflammation, oxidative stress, and tissue damage

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The increased expression of UPR target genes, including ATF4 , DDIT3 , TRIB3 , GADD34 , uXBP1 , and sXBP1 , identified by RNA-seq, was validated in MNNG/HOS and U2OS cell lines using RT-qPCR (Fig