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His reticence to discuss the idea was not unfounded

Both in vivo and in vitro studies have shown that olfactory ensheathing cells produce myelin components and secrete molecules related to myelination, such as P0, allowing them to form myelin of the appropriate size around demyelinated axons

"Vitamin B12 Supplementation: Preventing Onset and Improving Prognosis of Depression"

Unlike ordinary freckles in these locations, these lesions are not related to sun exposure, and are considered virtually pathognomonic of NF-1 (Crowes sign)