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10.1016/j.nicl.2016.03.017 40

) and iv) transition-metal catalysed formation of free radicals [64, 89]

PNAS 105(8):30113016

Several specific mechanisms of immune cell mitochondrial dysfunction in the perioperative period have been identified: 2.1.3.1 Warburg-like effect in innate immune cells The Warburg effect, first described by Otto Warburg in the 1920s, refers to the phenomenon wherein cancer cells preferentially metabolize glucose via aerobic glycolysis rather than oxidative phosphorylation, even in the presence of adequate oxygen (55)