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Further, an oxidative stress induced damage to the membrane of the cells which line the bile canaliculi (cells which are rich in GGT) may also contribute to the observed increase in the activity of this enzyme in plasma

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Figure 1 Circulating Fe 3+ attaches to the transferrin receptor and is transported into the cell via transferrin receptor 1 (TFR1) ( 3+ is reduced and released into the labile iron pool (LIP) of the cytosol ( 2+