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Without supplementation, deficiency is nearly universal within 23 years People taking metformin long-term metformin use reduces B12 absorption by 1030% through calcium-dependent ileal uptake disruption [4] People taking PPIs or H2 blockers acid suppression impairs B12 release from food proteins

Gastric ulcer protection: BPC-157s original characterization was as an anti-ulcer peptide, and its gastroprotective effects against alcohol, capsaicin, stress-induced, and NSAID-induced gastric lesions have been demonstrated across numerous published studies