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By increasing free iron through ferritin autophagy, a selective autophagy mechanism that targets ferritin, ferritin might encourage ferroptosis (Li et al., 2022)

Because high glucose levels increase oxidative stress, maintaining adequate antioxidant defenses is an important part of metabolic optimization

These include upregulating the Bax/Bcl-2 ratio in the mitochondria, 357 inducing HIF-1 degradation, 358 and involving with NF-B pathway 359 (Fig