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The first description of PIMD dates back to 1899 when Gowers reported a case of writers cramp that presumably emerged after wrist sprain [ 5 ]

[13] Dose escalation should proceed cautiously, with monitoring of vital signs, electrolytes, and-if relevant-ammonia levels

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An increase in SOD, CAT and GPx activities by the use of quercetine can exert beneficial effects on arrhythmias by affecting ion channels, Ca 2+ homeostasis, gap junction, suppressing cardiac fibrosis or inflammation and by inhibition or regulation of critical signaling pathways involved in arrhythmias, such as TGF-/Smad, NF-B, and PI3K/AKT (Zhou et al., 2022)