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Description

Transcription of EpCAM target genes, including c-Myc cyclins and TCF1, is activated as a result of translocation of -catenin bound to FHL2 and EpICD into the nucleus [97, 98]

The company plans to file a resubmission shortly, which it said would trigger another six-month review cycle and a new target action date

Minshall, R

Regulatory authorities advise assessing how renal and hepatic impairment affects the pharmacokinetics of new drugs, as this evaluation may indicate the need for dose adjustment in these populations [12,13,14,15]