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Cells were cultured in a 250-mL conical flask in a shaker at 37 C with 5%(v/v) CO 2 and 130 rpm shaking

More recent findings suggest that NAC corrects the alterations in glutamate homeostasis associated with drug addiction by inducing GLT1, a glial transporter that clears extracellular glutamate and inhibits the activation of extrasynaptic receptors that are involved in the induction and expression of maladaptive synaptic plasticity, such as mGlu5 receptors [117]

for example, a phase II study (NCT00928707) showed that SAHA combined with hydroxyurea was well tolerated (166)

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