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Esposito E, Pozza E, Contado C, Pula W, Bortolini O, Ragno D, et al

These traditional uses are supported primarily by ethnopharmacological evidence, with modern validation emerging from experimental studies and a limited number of clinical trials

These investigations focus on laboratory-based examination of peptide structure confirmation, copper-binding behavior, molecular stability profiling, and signaling pathway analysis under defined analytical conditions

It is worth noting that both CLSI and EUCAST provide guidelines which are primarily aimed to test the susceptibility of new clinical isolates against known antimicrobials, and not so much for testing novel compounds against known isolates, in a high throughput screening approach in which generally tests single concentration for primary screening and dose response testing only for confirmational screening