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In fact, DENV-infected people with no detectable symptoms or before the onset of symptoms are significantly more infectious to mosquitoes than people with symptomatic infections as DENV viraemic individuals without clinical symptoms may be exposed to more mosquitoes through their undisrupted daily routines than sick people

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High-dose ferric ammonium citrate (FeAC) triggers MM cell death with concurrent elevation of MDA - a lipid peroxidation byproduct and hallmark of ferroptosis, establishing iron metabolism as a critical modulator in MM pathophysiology ( 6.3 Oxidative stress pathway Emerging evidence demonstrates that andrographolide, a natural bioactive compound, induces ferroptosis in MM cells via P38-mediated suppression of the Nrf2/heme oxygenase-1 (HO-1) signaling axis, thereby triggering oxidative stress ( 6.4 Autophagy pathway Beclin-1, a core autophagy-related protein, drives autophagosome formation, while UNC-51 like kinase 1 (ULK1) coordinates autophagic initiation through its kinase complex (Zhong et al., 2020)

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