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Two weeks of treatment with lion's mane mycelia reduced immobility time in stress tests and activated BDNF pathways while blocking NF-B signals in mice [8]

In neuroinflammatory models, BHBA promotes microglia polarization toward M2, which exerts anti-inflammatory effects and prevents depressive-like behaviors (187)

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Homocysteine mediates transcriptional changes of the inflammatory pathway signature genes in human retinal pigment epithelial cells