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Abadi SHMH, Shirazi A, Alizadeh AM, Changizi V, Najafi M, Khalighfard S, et al

J.SidorovaJ.PedragosaJ.FiguerolaS.et al (2023)

Glossary AD Alzheimer's disease PD Parkinson's disease ALS amyotrophic lateral sclerosis HD Huntington's disease ROS Reactive oxygen species TRF transferrin TfR1 transferrin receptor 1 NCOA4 nuclear receptor coactivator 4 HSP90 heat-shock protein 90 IL-1 interleukin 1 IL-18 interleukin 18 GZMA proteins human granzyme family members GSDMB Gasdermin structural domain protein family member IFN- gamma interferon SLC7A11 solute carrier family 7 member 11 GSH glutathione PUFAs polyunsaturated fatty acids ALOX arachidonic acid lipoxygenase AA arachidonic acid AdA adrenoic acid PE phosphatidylethanolamine ACSL4 acetyl coenzyme a synthetase long-chain family 4 LPCAT3 lysophosphatidylcholine acyltransferase 3 CPY450 cytochrome P450 oxidoreductase hephaestin ferrous oxidase TFR1 transferrin receptor 1 STEAP3 prostate hexagonal transmembrane epithelial antigen 3 DMT1 divalent metal transporter protein 1 NCOA4 nuclear receptor coactivator 4 FPN1 iron transporter protein 1 CP Ceruloplasmin RSL3 GSH peroxidase 4 inhibitor HO-1 heme oxygenase-1 NRF2 nuclear factor erythrocyte 2-related factor 2 PLOOH phospholipid hydroperoxides MDA malondialdehyde 4-HNE 4-hydroxynonenal GPX4 glutathione peroxidase 4 PCBP1 chaperonin poly(rC)-binding protein 1 ACSL4 acyl coenzyme a synthase long-chain family member 4 LPCAT3 lysophosphatidylcholine acyltransferase 3 PTGS2 Prostaglandin peroxidase synthase 2 PPAR peroxisome proliferator-activated receptor OS Oxidative stress NADPH nicotinamide adenine dinucleotide phosphate NOX NADPH oxidase XO xanthine oxidase DPP4 dipeptidyl peptidase 4 VDAC voltage-dependent anion channel PLs phospholipids CoQ10 coenzyme Q10 GCL Glutamate cysteine ligase BSO L-buthionine sulfoximine TBH t-butyl hydroperoxide Fer-1 Ferrostatin-1 Lip-1 Liproxstatin-1 SOD1 Superoxide dismutase 1 ETC electron transport chain MGST1 Microsomal glutathione S-transferase 1 STING1 Stimulator Of Interferon Response CGAMP Interactor 1 ESCRT-III Endosomal Sorting and Transport Complex-III ER endoplasmic reticulum GSS glutathione synthetase Sec selenocysteine MVA mevalonate SAS Sulfasalazine DHODH Dihydroorotic acid dehydrogenase GCH1 GTP Cyclic Hydrolyserase 1 BH4 Tetrahydrobiopterin Keap1 kelch-like ech-related protein1 AREs antioxidant response elements HCC hepatocellular carcinoma cGAS-STING (cGAMP) synthase-interferon gene-stimulating factor dsDNA double-stranded DNA TBK1 tank-binding kinase1 IFN interferon IRF3 interferon regulatory factor3 ISGs IFN-stimulated genes MFN mitofusin gene DHA docosahexaenoic acid DFO Deferoxamine HIF1 Hypoxia-inducible factor 1 APP amyloid precursor protein APP apolipoprotein E PSEN1 progerin1 PSEN2 progerin2 A Amyloid beta NFTs neurofibrillary tangles MRI magnetic resonance imaging DFP deferiprone BACE1 beta-site amyloid precursor cleaving enzyme-1 TNF tumor necrosis factor MPTP 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine DA dopamine 6-OHDA 6-hydroxydopamine APP-/- APP knockout mouse model SN substantia nigra LB(s) Lewy bodies D-PUFAs Deuterated polyunsaturated fatty acids DA 3-hydroxytyramine Cu(II)ATSM a positron emission tomography developer sensitive to hypoxia MPP+ 1-methyl-4-phenylpyridinium HTT Huntington's protein mHtt mutant Htt 3-NP 3-nitropropionic acid GST glutathione S-transferase HSP27 Heat shock protein 27 CNS central nervous system SOD1 Superoxide dismutase1 GPX 4 NIKO GPX 4 neuron induced knockout