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By inhibiting the same transcription factor, miR-34a has been associated with an increase in cholesterol production in MASLD patients by maintaining 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) in its active form and decreasing the activation of AMPK, a key enzyme in energy consumption [298]

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Discussion The efficacy and safety of phytochemicals, endogenous compounds, and micronutrients in AD prevention and treatment are supported by promising preclinical evidence, yet their translation into clinical practice remains challenging