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Emerging evidence further indicates that MTs particularly MT1 and MT2A constitute a critical cytoplasmic defense layer against cuproptosis by acting as effective copper sponges that sequester excess Cu + and restrict its aberrant interaction with mitochondrial targets 170,173,174

In MPTP/MPP+-induced PD models, GTD significantly alleviated motor deficits and increases p-MEK/MEK, p-ERK/ERK, and p-CREB/CREB ratios, indicating activation of the MEK/ERK/CREB signaling pathway

In the present study, the expression of ferroptosis-related factors in hyperglycemia-induced HK-2 cells were evaluated as a positive control, with erastin utilized as a reference

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