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Loss of firmness or elasticity

We also provide an update on the targets and clinical prospects of different antioxidants (melatonin, N-acetylcysteine, vitamins, -lipoic acid, mineral elements, phytochemicals, nutritional antioxidants, cytoprotectants and synthetic compounds) in the treatment of CIPN with the help of preclinical and clinical studies, emphasizing the great potential of antioxidants as adjuvant strategies to mitigate CIPN

HDL stands for high-density lipoprotein

Possible symptoms and complications include hypoketotic hypoglycaemia, metabolic acidosis, hypotonia, hepatomegaly, encephalopathy, feeding problems, nausea, vomiting, lethargy, arrhythmias and often cardiomyopathy