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Description

Two common problems stand out

This important preclinical study showed that ketamine and other NMDAR antagonists produce fast-acting antidepressant-like effects in mouse models that depend on the rapid synthesis of BDNF via a mechanism that includes the deactivation of eEF2 kinase

In principle, the use of the unsuppressed water signal as a reference for metabolite signal normalization might introduce spurious correlations between glutathione and glutamate signals