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5 Paxillin, a focal adhesion scaffolding protein that binds directly to FAK and mediates cytoskeletal remodeling, is phosphorylated in BPC-157-treated endothelial cells in a pattern consistent with enhanced migratory phenotype precisely the phenotype required for endothelial cells to form new capillary tubes during angiogenesis

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Through high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based molecular weight identification, standard molecular weight comparison, and characteristic HPLC profiles of the [ 3 H]proline and [ 3 H]BPC157 standards (Supplementary Figure S2), we speculated the structures of these six components and designated them as M1M6 (Table 10)