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Moreover, NEDD4 knockdown in HK-2 cells was adequate to inhibit the ubiquitination of PPAR (Fig

Disclosure of interest: All authors: nothing to disclose 2 - Acute I 01.00 - ACUTE ISCHEMIC STROKE MANAGEMENT - 01.02 - ACUTE MANAGEMENT - Thrombolysis or thrombectomy P603 - ESOC25-2124 ANESTHESIA STRATEGIES IN ENDOVASCULAR TREATMENT FOR DISTAL OR MEDIUM VESSEL OCCLUSIONS: PROPENSITY SCORE ANALYSIS OF THE MR CLEAN REGISTRY AND META-ANALYSIS OF SIX STUDIES Mohamed Doheim 1 , Robrecht Knapen *2 , Diederik Dippel 3 , Julie Staals 2 , Jeannette Hofmeijer 4 , Adriaan van Es 5 , Jonathan Coutinho 6 , Christiaan Van der Leij 2 , Raul Nogueira 1 , Robert van Oostenbrugge 2 , Wim Van Zwam 2 1 Stroke Institute, Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States, 2 Maastricht University Medical Center +, Maastricht, Netherlands, 3 Erasmus University Medical Center, Rotterdam, Netherlands, 4 Rijnstate Hospital, Arnhem, Netherlands, 5 Leiden University Medical Center, Leiden, Netherlands, 6 University of Amsterdam, Amsterdam, Netherlands Background and Aims: The optimal anesthesia strategy for endovascular treatment (EVT) of anterior circulation distal or medium vessel occlusions (DMVOs) remains uncertain

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