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26 Collectively, abnormal amino acid metabolism can lead to excessive ROS production, causing oxidative stress and cellular damage, which ultimately exacerbates lung injury and worsens ARDS severity

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However, we believe that the participation of SPT16 in H1 removal is unlikely as SSRP1 is able to bind somatic nuclei in the absence of detectable SPT16 before nuclei incubation in egg extract (Supplementary Fig