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10.1111/apt.13291 [DOI] [PMC free article] [PubMed] [Google Scholar] 125

Studies have shown that exposure to high glucose or palmitate can lead to the downregulation of MFN1 and upregulation of DRP1 in renal cells, indicating altered mitochondrial dynamics and increased mitochondrial division [34]

Cooking has an enormous impact on glutathione levels and absorption, but some cooking methods may reduce the heat-sensitive glutathione

It is possible that the increased binding with mutant FUS/TLS interferes with the normal dynamics of SMN complex assembly and/or trafficking/cycling, therefore leading to dysregulation of SMN function