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Similarly, the Cu chaperone ATOX1 has also been found to serve as a modulator of angiogenesis, the depletion of Atox1 inhibit the migration of vascular smooth muscle cell that is stimulated by platelet-derived growth factor (PDGF), suggesting that ATOX1 likely plays a role in vascular remodeling and tumor angiogenesis

While it was of additive effect on ALT, creatinine, GSH and CAT, while it was of antagonist effect on tumor volume, Casp-3, Nf-kB, p38MAPK, and cyclin D1, Table 2