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According to their chemical composition, natural products can be subclassified into: alkaloids, carotenoids, nitrogen-containing compounds, organosulfur compounds, and phenolic compounds, the latter being the group that has the greatest in vitro effect on AML cells, perhaps because they are one of the substances more widespread among plants ( Currently, there are natural products that have been used in the treatment of ALL and AML, such as vincristine, an alkaloid derived from Catharanthus roseus , and etoposide, a semisynthetic derivative of podophyllin obtained from Podophyllum (Lucas et al., 2010)

HDAC6-mediated deacetylation of cortactin enhances its ability to bind to F-actin, thereby promoting actin polymerization and cell motility

The GST pull-down assay facilitates the isolation of key signaling proteins and their partners, allowing researchers to dissect signaling cascades and identify crucial regulatory components

Results NAMPT is a prognostic factor and a potential therapeutic target against 3D-spheroids with cancer stemness features To morphologically mimic floating cell clusters in the peritoneal cavity of patients with OV [15], we obtained various non-adherent cell lines that proliferated while suspended in the medium using ULA plates (Supplementary Fig