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Topical steroid withdrawal (TSW) is a recognized complication where eczema patients who discontinue long-term steroid use experience severe rebound inflammation

Ultimately, these debates converge on a central translational question: is ROS itself a druggable target, as evidenced by the success of ROS-inducing chemo-immunotherapies [222,223,224,225] and nanomedicines [278, 291, 335], or is its true utility as a predictive biomarker for patient stratification [235, 236]