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The family of bHLH proteins, which is involved in many essential biological processes, is very common in all eukaryotic organisms [223]

(One caution: since GHK-Cu is a copper-based ingredient, some experts suggest avoiding layering it at the exact same time as strong vitamin C products, as pure vitamin C (ascorbic acid) might bind copper

In cytoplasm, rapid autophagy induction by spermidine administration is achieved through inhibition of the lysine acetyltransferase EP300 (E1A-binding protein p300), primarily resulting in autophagy-relevant cytosolic protein deacetylation 30